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I joined the Neuroscience Program of Cook Children's in 2009 as a pediatric epileptologist, and now serve as the Medical Director of the Epilepsy Monitoring Unit and Tuberous Sclerosis Complex clinic. My clinical and research interests focus on the treatment of childhood onset epilepsy, specifically those patients with uncontrolled epilepsy or those for which the cause has not been determined. I have an intense interest in the use of surgical therapies to treat and cure epilepsy. The majority of my research has investigated the use of multimodal imaging techniques to localize seizure onset, as well as the description of patient and disease characteristics that predict favorable outcomes from surgical therapies. The pool of candidates which may benefit from surgical therapy continues to expand and I came to Cook Children's specifically because the staff of the Epilepsy Monitoring Unit and Comprehensive Epilepsy Program were dedicated to improving the care of children with epilepsy through cutting-edge techniques, research, and concern for their patients' well being.
In addition to my interest in surgical therapies, I care for a number of patients with epilepsy secondary to genetic disease. As our understanding of epilepsy has progressed and the sophistication of genetic testing has evolved, many new gene mutations have been discovered which lead to epilepsy. These syndromes often have certain characteristics for which treatment choices may be altered and outcome changed based on understanding the genetic mutation present. Many patients may have suffered years with uncontrolled epilepsy of unknown cause, but upon reevaluation a diagnosis may be made. With these patients in mind, I created the Genetic Epilepsy Clinic at Cook Children's, along with my partners in genetics, to improve the diagnosis, understanding, and treatment of children with these rare conditions.
Outside of my clinical and research interests, I serve on a number of local, national, and international committees dedicated to improving the care of childhood onset epilepsy. My free time is often spent with my wife and two daughters- usually at one of their dance competitions. I enjoy music of all types as well as collecting art, especially pieces related to the blues and my childhood home of the Mississippi Delta region.
Warncke K, MS Perry. "Redox state dependence of rotamer distributions in tyrosine and neutral tyrosyl radical." Biochimica et Biophysica Acta 2001,1545: 1-5.
Perry MS, PJ Holt, JT Sladky. "Topiramate loading for refractory status epilepticus in children." Epilepsia 2006, 47(6): 1070-1.
Perry MS, L Billars. "Extravasation of hyperalimentation into the spinal epidural space from a central venous line." Neurology 2006, 67: 715.
Perry MS, Benatar M. "Efficacy and tolerability of levetiracetam in children younger than 4 years: a retrospective review." Epilepsia 2007, 48(6):1123-1127.
Perry MS, Holt PJ, Benatar M. "Levetiracetam versus carbamazepine monotherapy for partial epilepsy in children < 16 years old." Journal of Child Neurology 2008, 23:515-519.
Perry MS, Sladky JT. "Neuroradiological Findings in Sengers Syndrome." Pediatric Neurology 2008, 39(2):113-5.
Burton LJ, Perry MS, Simon HK. Headache in the Pediatric Patient. In Harwood-Nuss' The Clinical Practice of Emergency Medicine, 5th Ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2009.
Perry MS, Duchowny M. Hemimegalencephaly. In S.Shorvon,R. Guerrini, and F. Andermann (Eds) The Causes of Epilepsy. Cambridge, UK: Cambridge University Press, 2011:289-292.
Perry MS, Dunoyer C, Dean P, Bhatia S, Bavariya A, Ragheb J, Miller I, Resnick T, Jayakar P, Duchowny M. "Predictors of Seizure-Freedom After Incomplete Resection in Children." Neurology 2010, 75(16):1448-53.
Wright R, Hernandez A, Malik S, Donahue DJ, Alles A, Perry MS. "Dravet syndrome associated with cortical dysplasia of Taylor-type." Journal of Pediatric Neurology 2011, 9:479-81.
Lupashko S, Malik S, Donahue DJ, Hernandez A, Perry MS. "Palliative functional hemispherectomy for the treatment of refractory status epilepticus associated with Alper's syndrome." Child's Nervous System 2011, 27(8):1321-3.
Perry MS and Duchowny M. "Surgical management of intractable childhood epilepsy: curative and palliative procedures." Sem Ped Neuro 2011, 18(3):195-202.
Perry MS, C Swint, J Hawley,S Kohler, S Blake, K Rask, J Sladky, N Krawiecki. Caregiver Measures for Seizure Control, Efficacy, and Tolerability of Antiepileptic Drugs for Childhood Epilepsy: Results of a Preference Survey. Epilepsy and Behavior 2011, 22(3):542-7.
Perry MS, Bailey LJ, Kotecha AC, Malik SI, Hernandez AW. Amantadine for the treatment of refractory absence seizures in children. Pediatric Neurology 2012, 46: 243-5.
Perry MS, Bailey LJ, Malik S, Gilson C, Kotecha A, Hernandez AW. Clobazam for the treatment of refractory epilepsy in children. Journal of Child Neurology 2013, 28(1):34-9.
Olson L, Perry MS. Localization of epileptogenic foci using multimodal imaging. Intern J of Neural Syst 2013, 23(1):1230001.Luke RR, Malik SI, Hernandez AW, Donahue DJ, Perry MS. Atypical imaging evolution of Sturge-Weber syndrome without facial nevus. Pediatric Neurology 2013, 48(2)143-5.
Brna P, Dooley JM, Esser JM, Perry MS, Gordon KE. Are YouTube seizures misleading? Neurologists don’t always agree. Epilepsy and Behavior 2013 (in press)
Perry MS, Duchowny MS. Surgical versus medical treatment for refractory epilepsy: outcomes beyond seizure control. Epilepsia 2013 (in press)Little W, Perry MS, Simon HK. Headache in the Pediatric Patient. In Harwood-Nuss’ The Clinical Practice of Emergency Medicine, 6th Ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2013 (in press)
Perry MS, Duchowny MS. Evaluation of intractable epilepsy. In Principles and Practice of Pediatric Neurosurgery, 3rd Ed. (eds Albright L, Pollack I, Adelson D) Thieme Medical Publishers, 2013. (in press)
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