Dr. Varughese attended Texas A&M University and received a B.S. in Biomedical Sciences. She attended medical school at the University of Texas Health Science Center in Houston, Texas and completed her residency at Stony Brook University Hospital, Long Island, New York. She was then appointed Clinical Professor of Pediatrics from 2005-2006. After that, she joined a private practice in New Jersey for five years. She moved back to her hometown of Dallas, TX and joined Cook Children's Physician Network in Lewisville in 2013.

She is married to Dr. Shane Varughese and has two children, Noah and Sarah. Dr. Varughese enjoys photography, cooking, and church activities. Her passion in life is taking care of children and educating families on preventative care and battling childhood obesity.