M. Scott Perry, MD
Medical Director, Neurology; Co-Director, Jane and John Justin Neurosciences Center; Medical Director, Genetic Epilepsy Clinic
Language(s):
- English
1500 Cooper St
Fort Worth, TX 76104
US
Meet Dr. M. Scott Perry
I joined the Neurosciences Program of Cook Children's in 2009 as a pediatric epileptologist, then served as the Medical Director of the Epilepsy Monitoring Unit and Tuberous Sclerosis Complex clinic before assuming the role of Medical Director of Neurology in 2016. My clinical and research interests focus on the treatment of childhood onset epilepsy, specifically those patients with uncontrolled epilepsy or those for which the cause has not been determined. I have an intense interest in the use of surgical therapies to treat and cure epilepsy. The majority of my research has investigated the use of multimodal imaging techniques to localize seizure onset, as well as the description of patient and disease characteristics that predict favorable outcomes from surgical therapies. The pool of candidates which may benefit from surgical therapy continues to expand and I came to Cook Children's specifically because the staff of the Epilepsy Monitoring Unit and Comprehensive Epilepsy Program were dedicated to improving the care of children with epilepsy through cutting-edge techniques, research, and concern for their patients' wellbeing.
In addition to my interest in surgical therapies, I care for a number of patients with epilepsy secondary to genetic cause. As our understanding of epilepsy has progressed and the sophistication of genetic testing has evolved, many new gene mutations have been discovered which lead to epilepsy. These syndromes often have certain characteristics for which treatment choices may be altered and outcome changed based on understanding the genetic mutation present. Many patients may have suffered years with uncontrolled epilepsy of unknown cause, but upon reevaluation a diagnosis may be made. With these patients in mind, I created the Genetic Epilepsy Clinic at Cook Children's, along with my partners in genetics, to improve the diagnosis, understanding, and treatment of children with these rare conditions.
Outside of my clinical and research interests, I serve on a number of local, national, and international committees dedicated to improving the care of childhood onset epilepsy. My free time is often spent with my wife and two daughters- usually at one of their cheer competitions. I enjoy music of all types as well as collecting art, especially pieces related to the blues and my childhood home of the Mississippi Delta.
Services
- Management of refractory epilepsy
- Treatment with antiepileptic drugs/neuromodulation/dietary therapy/epilepsy surgery
- New drug development
- Diagnosis and management of genetic epilepsy syndromes
All Practice Locations
Affiliations
American Epilepsy Society
American Academy of Neurology
Child Neurology Society
Dravet Syndrome Foundation - Medical Advisory Board
Brain Recovery Project - Scientific Advisory Board
Epilepsy Foundation of Texas - Chair - Professional Advisory Board
Epilepsy Foundation of America - Professional Advisory Board
Cook Children's Physician Network
American Academy of Neurology
Child Neurology Society
Dravet Syndrome Foundation - Medical Advisory Board
Brain Recovery Project - Scientific Advisory Board
Epilepsy Foundation of Texas - Chair - Professional Advisory Board
Epilepsy Foundation of America - Professional Advisory Board
Cook Children's Physician Network
Recognitions
Super Doctors (2013-2015;2018-2019 Texas Rising Star)
Top Doc (2019 Fort Worth Magazine)
Mom-Approved Doctor (2015 DFW Child Magazine)
Endowed Chair recipient (2016-present Cook Children’s)
Healthcare Hero (2017 Ft Worth Business Press)
Researcher of the Month (Jan 2016 Cook Children’s Medical Center)
Top Research Abstract (Cook Children’s Research Day 2016)
PharmaTimes Clinical Researcher of the Year – Site Team Bronze Medal Winner (2018)
Education
Medical School:
University of Mississippi School of Medicine
Residency:
Emory University School of Medicine
Board Certifications:
American Board of Neurology with special competence in Child Neurology
American Board of Neurology - Epilepsy sub-specialty
Research & Publications
Publications:
- Perry MS, Dunoyer C, Dean P, Bhatia S, Bavariya A, Ragheb J, Miller I, Resnick T, Jayakar P, Duchowny M. "Predictors of Seizure-Freedom After Incomplete Resection in Children." Neurology 2010, 75(16):1448-53.
- Perry MS, Duchowny M. Hemimegalencephaly. In S.Shorvon,R. Guerrini, and F. Andermann (Eds) The Causes of Epilepsy. Cambridge, UK: Cambridge University Press, 2011:289-292.
- Wright R, Hernandez A, Malik S, Donahue DJ, Alles A, Perry MS. "Dravet syndrome associated with cortical dysplasia of Taylor-type." Journal of Pediatric Neurology 2011, 9:479-81.
- Lupashko S, Malik S, Donahue DJ, Hernandez A, Perry MS. "Palliative functional hemispherectomy for the treatment of refractory status epilepticus associated with Alper's syndrome." Child's Nervous System 2011, 27(8):1321-3.
- Perry MS, Duchowny M. "Surgical management of intractable childhood epilepsy: curative and palliative procedures." Sem Ped Neuro 2011, 18(3):195-202.
- Perry MS, C Swint, J Hawley,S Kohler, S Blake, K Rask, J Sladky, N Krawiecki. Caregiver measures for seizure control, efficacy, and tolerability of antiepileptic drugs for childhood epilepsy: results of a preference survey. Epilepsy and Behavior 2011, 22(3):542-7.
- Perry MS, Bailey LJ, Kotecha AC, Malik SI, Hernandez AW. Amantadine for the treatment of refractory absence seizures in children. Pediatric Neurology 2012, 46: 243-5.
- Perry MS, Bailey LJ, Malik S, Gilson C, Kotecha A, Hernandez AW. Clobazam for the treatment of refractory epilepsy in children. Journal of Child Neurology 2013, 28(1):34-9.
- Olson L, Perry MS. Localization of epileptogenic foci using multimodal imaging. Intern J of Neural Syst 2013, 23(1):1230001.
Luke RR, Malik SI, Hernandez AW, Donahue DJ, Perry MS. Atypical imaging evolution of Sturge-Weber syndrome without facial nevus. Pediatric Neurology 2013, 48(2)143-5. - Brna P, Dooley JM, Esser JM, Perry MS, Gordon KE. Are YouTube seizures misleading? Neurologists don't always agree. Epilepsy and Behavior 2013, 29(2):305-7.
- Perry MS, Duchowny MS. Surgical versus medical treatment for refractory epilepsy: outcomes beyond seizure control. Epilepsia 2013, 54(12): 2060-70.
- Little W, Perry MS, Simon HK. Headache in the Pediatric Patient. In Harwood-Nuss' The Clinical Practice of Emergency Medicine, 6th Ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2013
- Perry MS, Duchowny MS. Evaluation of intractable epilepsy. In Principles and Practice of Pediatric Neurosurgery, 3rd Ed. (eds Albright L, Pollack I, Adelson D) Thieme Medical Publishers.
- Sankar S, Chung S, Perry MS, Kuzniecky R, Sinha S. Clinical considerations in transitioning patients with epilepsy from clonazepam to clobazam: a case series. J Med Case Rep, 2014, Dec 16;8:429.
- Perry MS and Patel AD. American Board of Psychiatry and Neurology Certification in Epilepsy: Just what the doctor ordered, another board examination. Pediatric Neurology 2014, 51(5):598-599.
- Elias H, Perry MS. "Tuberous Sclerosis" In Dieckmann RA, Pitt WR, Schafermeyer RW, Young K, Fox S (editors-in-chief): "PEMSoft: The Pediatric Emergency Medicine Software", Version 9.0. EBSCO Publishing, Massachusetts, 2015.
- Elias H, Perry MS. "Infantile spasms" In Dieckmann RA, Pitt WR, Schafermeyer RW, Young K, Fox S (editors-in-chief): "PEMSoft: The Pediatric Emergency Medicine Software", Version 9.0. EBSCO Publishing, Massachusetts, 2015.
- Elias H, Perry MS. "Sturge Weber Syndrome" In Dieckmann RA, Pitt WR, Schafermeyer RW, Young K, Fox S (editors-in-chief): "PEMSoft: The Pediatric Emergency Medicine Software", Version 9.0. EBSCO Publishing, Massachusetts, 2015.
- Perry MS. (2015) "Tuberous Sclerosis Complex" Epilepsy.com
- Perry MS. Has progress been made in progressive myoclonic epilepsy (EPM1)?. Epilepsy Curr 2015, 15(5):253-254.
Fournier-Goodnight A, Gabriel M, Perry MS. Preliminary neurocognitive outcomes in Jeavons Syndrome. Epilepsy Behav 2015, 52(Pt A):260-263. - Hodges SL, Gabriel MT, Perry MS. Neuropsychological Findings Associated with Panayiotopoulos Syndrome. Epilepsy Behav 2016, 54:158-62.
- Daniel C, Perry MS. Ictal Coprolalia: A Case Report and Review of Ictal Speech as a Localizing Feature in Epilepsy. Ped Neuro 2016, 57:88-90.
- Fahrner JA, Liu R, Perry MS, Klein J, Chan DC. A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy. Am J Med Genet 2016; 170(8): 2002-11.
- Perry MS. Genetic testing in epileptic encephalopathy: Rosetta stone or just an expensive rock? Epil Currents 2016; 16:12-13.
- Perry MS. Are we winning the battle but losing the war? Sequelae of surviving epilepsy. Epil Currents 2016, 16:139-140.
- Perry MS. Meaningful results in a jiffy: a PERC of multicenter collaboration. Epil Currents 2016, 16(5): 299-301.
- Perry MS, Bailey L, Freedman D, Donahue D, Malik S, Head H, Keator C, Hernandez A. Coregistration of multimodal imaging is associated with favorable 2 year seizure outcome after pediatric epilepsy surgery. Epileptic Disorders 2017, 19(1): 40-8.
- Patel A, Perry MS. Febrile Seizures. Journal of Clinical Outcomes Management 2017, 24(7):325-334.
- Perry MS. Flat out unnecessary: Burst characteristics, not interbursts intervals, predict successful anesthetic wean in refractory status epilepticus. Epil Currents 2017, 17(3): 153-4.
- Turner A, Perry MS. Outside the box: Medications worth considering when traditional antiepileptic drugs have failed. Seizure 2017, 50:173-185.
- Perry MS, Donahue DJ, Malik SI, Keator CG, Hernandez A, Reddy RK, Perkins Jr FF, Lee MR, Clarke DF. MR-guided laser interstitial thermal therapy as treatment for intractable pediatric epilepsy of insular onset. J Neurosurg Pediatr. 2017, 20:575-582.
- Modi AC, Junger KF, Mara C, Kellerman T, Barrett L, Wagner J, Mucci G, Bailey L, Almane D, Guilfoyle SM, Urso L, Hater B, Hustzi H, Smith G, Herrmann B, Perry MS, Zupanc M, Varni JW. Validation of the PedsQL™ Epilepsy Module: A pediatric epilepsy-specific quality of life measure. Epilepsia 2017, 58:1920-30.
- Nguyen TTM, Murakami Y, Sheridan E, et al. Mutations in GPAA1, encoding a GPI transamidase complex protein, cause developmental delay, epilepsy, cerebellar atrophy and osteopenia. Am J Hum Genet 2017, 101:856-65.
- Perry MS and Poduri A. Two studies, one message: high yield of genetic testing in infants and young children with severe epilepsies. Epil Currents 2018, 18:24-6.
- Perry MS. Take two deep breaths and call me in the morning. Epil Currents 2018, 18:222-3. Turner A and Perry MS. Cannabis, cannabidiol, and epilepsy: Clinical considerations and practical applications. Pract Neuro Oct 2018
- Perry MS. Don't fear the reefer-evidence mounts for plant-based cannabidiol as treatment for epilepsy. Epil Currents 2019, 19:93-95.
- Johnson BV, Kumar R, Oishi S...Perry MS... et al. Partial Loss of USP9X function leads to a male neurodevelopmental and behavioural disorder converging on TGFβ signaling. Biol Psychiatry 2019, Jun 29.