Research Funding

1R01NS104116-01A1
National Institute of Neurological Disorders & Stroke

Interictal high frequency oscillations as non-invasive biomarkers of epileptogenicity in pediatric patients

Role Description: This RO1 application aims to non-invasively detect and reliably localize HFOs from pediatric patients with refractory epilepsy using high-density scalp electroencephalography (EEG) and magnetoencephalography (MEG), identify their onset generator, and correlate the resection of this generator with patients’ postsurgical outcome.

Principal Investigator: Christos Papadelis
Funding Period: Mar. 1, 2020 – Mar. 31, 2025

1R21NS101373-01A1

National Institute of Neurological Disorders & Stroke

Interictal frequency oscillations as non-invasive biomarkers of epileptogenicity in pediatric patients

Role Description: This R21 application aims to non-invasively detect and reliably localize HFOs from pediatric patients with refractory epilepsy using high-density scalp electroencephalography (EEG) and magnetoencephalography (MEG), identify their onset generator, and correlate the resection of this generator with patients’ postsurgical outcome.

Principal Investigators: Christos Papadelis and Steven Stufflebeam
Funding Period: Sept. 15, 2018 – Aug. 31, 2021

R21 HD090549

National Institutes of Health/National Institute of Child Health and Human Development

Multi-modal neuroimaging in children with congenital hemiplegia to assess functional and anatomical reorganization in relation to hand function

Role Description: The main goal of this study is to identify abnormal functional and anatomical brain reorganization associated with hand function in young children (18-24 months) with congenital hemiplegia due to unilateral periventricular white matter injury using multi-modal neuroimaging.

Principal Investigator: Christos Papadelis
Funding Period: Sept. 19, 2017 – Aug. 31, 2021

Encoded Therapeutics

Electrophysiological Biomarkers of GABA metabolism in children with Dravet Syndrome

Role Description: This project aims to utilize advanced noninvasive neuroimaging techniques known to depend on GABA signaling for assessing chronic depletion of GABA in children with Dravet Syndrome. The findings of this project will help us to understand the pathophysiological GABA mechanism in children with Dravet and potentially guide the development of future GABAergic modulation treatments.

Principal Investigator: Christos Papadelis

Funding Period: Sept. 1, 2022 – 31 Aug. 2024

Vivienne Redlich Charitable Trust

Noninvasive Biomarkers in Autism Spectrum Disorders

Role Description: The main aim of this project is to develop noninvasive electrophysiological biomarkers that helps the early diagnosis of autism and identify the neural correlates of the different underlying neurobehavioral phenotypes of the spectrum.

Principal Investigator: Christos Papadelis.

Funding Period: Jan. 1, 2024 – Dec. 31, 2024

Cook Children’s Health Foundation (Private Donors: Jeanie & Ken Huffman)

Functional Abnormalities in the GABAergic system in SYNGAP

Role Description: The main aim of this project is to identify abnormalities in the GABAergic brain mechanism that underlies SYNGAP-1 related neurological disorders, a rare group of genetic disorders characterized by moderate to severe intellectual disability that is evident in early childhood.

Principal Investigator: Christos Papadelis

Funding Period: Jan. 1, 2023 – Dec. 31, 2023

Employees Care Champion Funding, Cook Children’s Health Care System

Innovative Functional Neuro-monitoring to Assess Pain and Stress in Preterm Infants

Role Description: The main goal of the study is to develop a method that reliably quantifies the level of pain induced from clinically required noxious procedures to preterm infants hospitalized in the neonatal intensive care unit (NICU).

Principal Investigator: Christos Papadelis

Funding Period: Jan 1, 2023 – Dec 31, 2023

823958

Horizon 2020 - European Commission - MSCA-RISE-2018

Automatic detection and localization of high frequency oscillation in pediatric epilepsy

Role Description: This project aims to advance beyond the current state-of-the-art in high-frequency oscillations (HFOs) and medically refractory epilepsy (MRE), through staff exchanges with world-leading researchers in hardware and software development, applied neurosciences and neurofeedback, dynamic signal processing, epilepsy, and techno-economic analysis.

Principal Investigator: Manousos Klados
Site Principal Investigator: Christos Papadelis
Funding Period: Sept. 1, 2018 – Sept. 30, 2023

American Academy for Cerebral Palsy and Developmental Medicine
AACPDM/C-PROGRESS

Multi-modal neuroimaging in children with hemiplegia to assess brain functional network reorganization in relation to manual response inhibition

Role Description: Apply two advanced neuroimaging technologies, magnetoencephalography and high-density electroencephalography, to record brain magnetic and electric signals in children with hemiplegic cerebral palsy and typically developed controls while doing a behavioral task with sensory and movement components.

Principal Investigator: Yanlong Song
Funding Period: Jan. 1, 2021 – Dec. 31, 2021

Cook Children's Health Foundation

Functional Abnormalities in the GABAergic system with SYNGAP

Role Description: Several studies have shown evidence of GABA deregulation in genetic epilepsies. In this project, we will explore the pathophysiological mechanism of potential GABA deregulation in the genetic epilepsy disorder SYNGAP-1 using noninvasive electrophysiological techniques, such as the high-density EEG and the magnetoencephalography.

Principal Investigator: Christos Papadelis, M Scott Perry
Funding Period: Jan. 1, 2022 – Dec. 31, 2024

Jordan Elizabeth Harris Foundation

Cognitive and Neuroimaging Biomarkers of Well-being in Youth with and without Epilepsy

Role Description: The goal of this project is to investigate behavior and brain function as they relate to clinical aspects of pediatric epilepsy and depression.

Principal Investigator: Crystal Cooper
Funding Period: Jul. 1, 2021 – Jul. 1, 2022

CORE Grant – Cook Children's Research Development Council

Functional Connectivity estimated through Virtual Implantation predicts Surgical Outcome in Children with Epilepsy

Role Description: Children with drug resistant epilepsy go into presurgical evaluation with noninvasive measures. In this project, we explore the role of functional connectivity measures in the delineation of the epileptogenic zone and the prediction of surgical outcome in children with drug-resistant epilepsy.

Principal Investigator: Ludovica Corona
Funding Period: Dec. 1, 2021 – Nov. 30, 2022

CORE Grant – Cook Children's Research Development Council

Overlapping onset of spike and ripple propagations is more specific biomarker of epilepsy than fast ripples

Role Description: Children with drug resistant epilepsy often go for intracranial electroencephalography (iEEG) recordings. To delineate the epileptogenic zone, several stereotyped clinical seizures should be recorded. In this project, we will develop an interictal iEEG biomarker that detects the onset of propagating interictal spikes and high-frequency oscillations. Such a biomarker would augment the presurgical evaluation of children with drug resistant epilepsy and potentially improve their surgical outcome.

Principal Investigator: Saeed Jahromi
Funding Period: Dec. 1, 2021 – Nov. 30, 2022

CORE Grant – Cook Children's Research Development Council

Onset of Spike Propagation Identifies the Epileptogenic Zone in Children with Refractory Epilepsy: a Multimodal Electric Source and Diffusion Imaging Study

Role Description: Children with drug resistant epilepsy often go for intracranial electroencephalography (iEEG) recordings. To delineate the epileptogenic zone, several stereotyped clinical seizures should be recorded. In this project, we will develop an interictal iEEG biomarker that detects the onset of propagating interictal spikes using electric source imaging. Such a biomarker would augment the presurgical evaluation of children with drug resistant epilepsy and potentially improve their surgical outcome.

Principal Investigator: Margherita Matarrese
Funding Period: Dec. 1, 2021 – Nov. 30, 2022

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