Neuroscience Research

Redirecting to Pickin for Preemies

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When most people think of medical research they assume that the most advanced research comes from academic affiliations. But here at Cook Children's, we challenge that assumption. Our medical team is deeply involved in research of all kinds. We look for better ways to diagnose, treat and prevent neurological conditions ... and we look for ways to cure them.

Cook Children's is at the forefront of leading-edge clinical research and our specialists are actively participating in studies investigating a variety of conditions including epilepsy, stroke and neuromuscular disorders.

2020 published research

Tamilia E, Parker MS, Rocchi M, Taffoni F, Hansen A, Grant PE, Papadelis C. Nutritive Sucking Abnormalities and Brain Microstructural Abnormalities in Infants with Established Brain Injury - A Pilot Study. J Perinatol 2019; 1498-1508.
Alhilani M, Tamilia E, Ricci L, Ricci L, PE Grant, Madsen JR, Pearl PL, Papadelis C. Ictal and Interictal Source Imaging on Intracranial EEG Predicts Epilepsy Surgery Outcome in Children with Focal Cortical Dysplasia. Clin Neurophysiology 2020; 131 (3), 734-743.
Tamilia E, Dirodi M, Alhilani M, Grant PE, Madsen JR, Stufflebeam SM, Pearl PL, Papadelis C. Scalp Ripples as Prognostic Biomarkers of Epileptogenicity in Pediatric Surgery. Ann Clin Transl Neurology 2020; 7(3):329-342.
Papadelis C, Chen Y-H. Pediatric Magnetoencephalography in Clinical Practice and Research. Neuroimaging Clinics of North America 2020; 30(2): 239-248.
Touserkani FM, Tamilia E, Coughlin F, Hammond S, El Atrache R, Jackson M, BendsenJensen M, Kim B, Connolly J, Manganaro S, Papadelis C, Kapur K, Loddenkemper T. Photoplethysmographic evaluation of generalized tonic-clonic seizures. Epilepsia 2020; doi: 10.1111/epi.16590.
El Atrache R, Tamilia E, Mohammadpour Touserkani F, Hammond S, Papadelis C, Kapur K, Jackson M, Bucciarelli B, Tsuboyama M, Sarkis RA, Loddenkemper T. Photoplethysmography: a measure for the function of the autonomic nervous system in Focal Impaired Awareness Seizures. Epilepsia 2020; doi: 10.1111/epi.16621.
Miller I, Scheffer IE, Gunning B, Sanchez-Carpintero R, Gil-Nagel A, Perry MS, Saneto RP, Checketts D, Dunayevich E, Knappertz V; GWPCARE2 Study Group. Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome: A Randomized Clinical Trial. JAMA Neurol. 2020;77(5): 613-621.
Arocho-Quinones EV, Lew SM, Handler MH, Tovar-Spinoza Z, Smyth M, Bollo R, Donahue D, Perry MS, Levy ML, Gonda D, Mangano FT, Storm PB, Price AV, Couture DE, Oluigbo C, Duhaime AC, Barnett GH, Muh CR, Sather MD, Fallah A, Wang AC, Bhatia S, Patel K, Tarima S, Graber S, Huckins S, Hafez DM, Rumalla K, Bailey L, Shandley S, Roach A, Alexander E, Jenkins W, Tsering D, Price G, Meola A, Evanoff W, Thompson EM, Brandmeir N; Pediatric Stereotactic Laser Ablation Workgroup. Magnetic resonance-guided stereotactic laser ablation therapy for the treatment of pediatric brain tumors: a multiinstitutional retrospective study. J Neurosurg Pediatr. 2020:1-9.
Perry MS. Age Is Just a Number: Adults Deserve the Same Access to Genetic Testing as Children. Epilepsy Curr. 2020; 20(1): 14-15.
Perry MS. New and Emerging Medications for Treatment of Pediatric Epilepsy. Pediatr Neurol. 2020; 107: 24-27.
Turner AL, Shandley S, Miller E, Perry MS, Ryals B. Intranasal Ketamine for Abortive Migraine Therapy in Pediatric Patients: A Single-Center Review. Pediatr Neurol. 2020; 104: 46-53.
Johnson BV, Kumar R, Oishi S, Alexander S, Kasherman M, Vega MS, Ivancevic A, Gardner A, Domingo D, Corbett M, Parnell E, Yoon S, Oh T, Lines M, Lefroy H, Kini U, Van Allen M, Grønborg S, Mercier S, Küry S, Bézieau S, Pasquier L, Raynaud M, Afenjar A, Billette de Villemeur T, Keren B, Désir J, Van Maldergem L, Marangoni M, Dikow N, Koolen DA, VanHasselt PM, Weiss M, Zwijnenburg P, Sa J, Reis CF, López-Otín C, Santiago-Fernández O, Fernández-Jaén A, Rauch A, Steindl K, Joset P, Goldstein A, Madan-Khetarpal S, Infante E, Zackai E, Mcdougall C, Narayanan V, Ramsey K, Mercimek-Andrews S, Pena L, Shashi V; Undiagnosed Diseases Network, Schoch K, Sullivan JA, Pinto E Vairo F, Pichurin PN, Ewing SA, Barnett SS, Klee EW, Perry MS, Koenig MK, Keegan CE, Schuette JL, Asher S, Perilla-Young Y, Smith LD, Rosenfeld JA, Bhoj E, Kaplan P, Li D, Oegema R, van Binsbergen E, van der Zwaag B, Smeland MF, Cutcutache I, Page M, Armstrong M, Lin AE, Steeves MA, Hollander ND, Hoffer MJV, Reijnders MRF, Demirdas S, Koboldt DC, Bartholomew D, Mosher TM, Hickey SE, Shieh C, Sanchez-Lara PA, Graham JM Jr, Tezcan K, Schaefer GB, Danylchuk NR, Asamoah A, Jackson KE, Yachelevich N, Au M, Pérez-Jurado LA, Kleefstra T, Penzes P, Wood SA, Burne T, Pierson TM, Piper M, Gécz J, Jolly LA. Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling. Biol Psychiatry. 2020; 87(2): 100-112.
Tidball AM, Lopez-Santiago LF, Yuan Y, Glen TW, Margolis JL, Walker JC, Kilbane EG, Miller CA, Bebin EM, Perry MS, Isom LL, Parent JM. Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons. Brain 2020 (in press)
Grinspan ZM, Mytinger JR, Baumer FM, Ciliberto MA, Cohen BH, Dlugos DJ, Harini C, Hussain SA, Joshi SM, Keator CG, Knupp KG, McGoldrick PE, Nickels KC, Park JT, Pasupuleti A, Patel AD, Shahid AM, Shellhaas RA, Shrey DW, Singh RK, Wolf SM, Yozawitz EG, Yuskaitis CJ, Waugh JL, Pearl PL. Management of Infantile Spasms During the COVID-19 Pandemic. J Child Neurol. 2020: 883073820933739.
Grinspan ZM, Mytinger JR, Baumer FM, Ciliberto MA, Cohen BH, Dlugos DJ, Harini C, Hussain SA, Joshi SM, Keator CG, Knupp KG, McGoldrick PE, Nickels KC, Park JT, Pasupuleti A, Patel AD, Pomeroy SL, Shahid AM, Shellhaas RA, Shrey DW, Singh RK, Wolf SM, Yozawitz EG, Yuskaitis CJ, Waugh JL, Pearl PL; Child Neurology Society (Practice Committee and Executive Board) and the Pediatric Epilepsy Research Consortium (Infantile Spasms Special Interest Group and Steering Committee). Crisis Standard of Care: Management of Infantile Spasms during COVID-19. Ann Neurol. 2020: 10.1002/ana.25792.
Marks WA, Acord S, Bailey L, Honeycutt J. Neuromodulation in childhood onset dystonia: evolving role of deep brain stimulation. Curr Phy Med Rehab Reports 2020;8:37-43.

Gaetz W, Papadelis C, Wilson T. Clinical Motor Mapping with MEG: Historical Approaches, Challenges and Recommendations for Best Practice. In: Fifty Years of Magnetoencephalography. Edited by: A.C. Papanicolaou, T.P.L. Roberts, and J.W. Wheless. 2020; Oxford University Press.

Alhilani M, Tamilia E, Ricci L, Grant PE, Alter A, Peters JM, Pearl PL, Madsen JR, Papadelis C. Clinical Utility of Electric Source Imaging on Intracranial Electroencephalography in Children with Focal Cortical Dysplasia. 2019 Annual Meeting of the American Epilepsy Society, December 06-10, 2019, Baltimore, Maryland, USA (Poster).
Ntolkeras G, Tamilia T, AlHilani M, Madsen JR, Stufflebeam S, Pearl PL, Papadelis C. Pre-surgical Ability of Magnetic and Electric Source Imaging to Localize the Epileptogenic Zone in Children with Focal Cortical Dysplasia. 2019 Annual Meeting of the American Epilepsy Society, December 06-10, 2019, Baltimore, Maryland, USA (Poster).
El Atrache R, Tamilia E, Hammond S, Mohammadpour Touserkani F, Papadelis C, Kapur K, Jackson M, Ufongene C, Schubach S, Bucciarelli B, Tsuboyama M, Sarkis R, Loddenkemper T. Photoplethysmography detects blood volume pressure changes in the pre-ictal and post-ictal periods in patients with Focal Impaired Awareness Seizures. 2019 Annual Meeting of the American Epilepsy Society, December 06-10, 2019, Baltimore, Maryland, USA (Poster) * 2019 Grass Foundation Young Investigator Award
Ricci L, Tamilia T, Alhilani M, Grant PE, Alter A, Madsen JR, Peters JM, Pearl PL, Papadelis C. Electrical Source Imaging of Seizure Onset Zone with Conventional 20-Channel EEG is predictive of Surgical Outcome in Children with Epilepsy. 2019 Annual Meeting of the American Epilepsy Society, December 06-10, 2019, Baltimore, Maryland, USA (Poster) * Selected to be presented as a talk in the pediatric highlights of the conference.
Tamilia E, Dirodi M, Madsen JR, Stufflebeam SM, Pearl PL, Papadelis C. Pre-surgical Electric and Magnetic Source Imaging of Scalp-recorded Ripples in Children with Epilepsy: Concordance with Intracranial EEG and Epileptogenic Zone. 2019 Annual Meeting of the American Epilepsy Society, December 06-10, 2019, Baltimore, Maryland, USA (Poster) * 2019 Grass Foundation Young Investigator Award
Alhilani M, Tamilia E, Ricci L, Grant PE, Alter A, Peters JM, Pearl PL, Madsen JR, Papadelis C. Clinical Utility of Electric Source Imaging on Intracranial Electroencephalography in Children with Focal Cortical Dysplasia. European Congress of Radiology (ECR) 2020 Annual Congress. 11-15 March, 2020, Vienna, Austria (Poster) * 2020 ECR “Invest in the Youth” Award
Papadelis C, Ntolkeras G, DiBacco ML, AlHilani M, Nunes D, Roullet J-B, Gibson K.M., Pearl PL. Gamma Suppression on Somatosensory Evoked Potentials in Patients with Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD), a hyper-GABAergic Condition. 16th International Child Neurology Congress / 49th Annual Child Neurology Society Meeting; Virtual conference.
Perry MS, Patel A, Gil-Nagel A, Chin R, Mitchel W, Weinstock A, Roberts C, Whyte L, Vanlandinham K. Long-term Safety and Efficacy of Add-on Cannabidiol (CBD) Treatment in Patients with Lennox Gastaut Syndrome in an Open-label Extension Trial (GWPCARE5). Child Neurology Society Meeting, Charlotte NC, 2019.
Perry MS, Miller I, Scheffer I, Gunning B, Sanchez-Carpintero R, Gil-Nagel A, Saneto R, Checketts D, Whyte L, Dunayevich E, Knappertz V. Cannabidiol (10 and 20 mg/kg/d) significantly reduces convulsive seizure frequency in Dravet syndrome: results of a phase 3 trial (GWPCARE2) Child Neurology Society Meeting, Charlotte, NC, 2019.
Perry MS, Wong-Kisiel L, Singh R, McGoldrick P, Wolf S, Mohamed I, McNamara N, Romanowski E, Shrey D, Chapman K, Bolton J, Marashly A, Clareke D, Akman C, Grinspan Z, Gedela S. Collaborating to improve epilepsy surgical care in children: the Pediatric Epilepsy Research Consortium (PERC) Surgery Subgroup. Child Neurology Society Meeting, Charlotte, NC, 2019.
Singh R, Wong-Kisiel L, Perry MS, Shandley S, McNamara N, Grinspan Z, Chapman K, McGoldrick P, Marashly A, Wolf S, Nangia S, Bolton J, Shrey D, Skjei K, Romanowski E, Tatachar P, Osterndorf A, Gedela S. Characteristics of patients referred for pediatric epilepsy surgery evaluation in the US: early findings from the PERC (Pediatric Epilepsy Research Consortium Epilepsy Surgery Subgroup. 73rd Annual American Epilepsy Society Meeting, Baltimore, MD, 2019.
Perry MS, Wong-Kisiel L, Singh R, Shandley S, McNamara N, Grinspan Z, Chapman K, McGoldrick P, Marashly A, Wolf S, Nangia S, Bolton J, Shrey D, Skjei K, Romanowski E, Tatachar P, Osterndorf A, Gedela S. Time to referral for epilepsy surgery evaluation is longer in older children with intractable epilepsy – a potential opportunity for improvement. 73rd Annual American Epilepsy Society Meeting, Pediatric Epilepsy Highlights Session, Baltimore, MD, 2019.
Schafer P, Farrell K, Kakacek J, Owens S, Schultz R, Shah A, Hueneke S, Joshi S, Perry MS, Newborn-Palmer L, Fain D, McPhillips A, Nasuta M, Doss J, Cushner-Weinstein S, Parsupuleti A, Rodecki L. Managing students with seizures ECHO: The importance of school nurses. 73rd Annual American Epilepsy Society Meeting, Baltimore, MD, 2019.
Sullivan J, Devinsky O, Galer B, Farfel G, Haney D, Perry MS, Auvin S, Gil-Nagel A, Gammaitoni A. ZX008 (Fenfluramine Hydrochloride oral solution) reduces seizure burden by significantly increasing number of seizure-free days and time between seizures in patients with Dravet syndrome. 73rd Annual American Epilepsy Society Meeting, Baltimore, MD, 2019.
Segal E, Miller I, Perry MS, Brunklaus A, Sameer Z, O’Donnell P, Tagliatela S, Maru B, Seda J, Kilian R, Gioia GA, Berl MM. Proposed design for a natural history study of SCN1A-positive (SCN1A+) Dravet syndrome. 73rd Annual American Epilepsy Society Meeting, Baltimore, MD, 2019.
Miller I, Dlugos D, Segal E, Giola G, Berl M, O’Donnell P, Tagliatela SM, Seda J, Kilian R, Perry MS. From gene replacement to gene regulation: developing a disease-modifying AAV gene therapy vector for SCN1A-positive (SCN1A+) Dravet Syndrome. 73rd Annual American Epilepsy Society Meeting, Baltimore, MD, 2019.
Patel AD, Chin RF, Mitchell W, Perry MS, Weinstock A, Checketts D, Dunayevich E. Long-term safety and efficacy of add-on cannabidiol in patients with Lennox-Gastaut syndrome: 3-year results of an open-label extension trial (GWPCARE5). 73rd Annual American Epilepsy Society Meeting, Baltimore, MD, 2019.
Schneider AL, Myers C, Muir AM, Calvert S, Basinger A, Perry MS, Rodan L, Helbig KL, Chambers C, Gorman K, Berkovic S, Mefford HC, Scheffer IE. Pathogenic variants in FBXO28 cause developmental and epileptic encephalopathy with profound impairment and movement disorders. 73rd Annual American Epilepsy Society Meeting, Baltimore, MD, 2019.
Perry MS, Wirrell E, Burkholder D, Galer B, Gammaitoni A. Real-world experience with ZX008 (Fenfluramine HCl) for the treatment of seizures in Dravet syndrome: initial report from United States expanded access program. American Academy of Neurology Annual Meeting 2020, Toronto, Ontario, Canada (canceled due to COVID19 pandemic)
Patel A, Chin R, Mitchell W, Perry MS, Weinstock A, Checketts D, Dunayevich E. Long-term safety and efficacy of cannabidiol (CBD) treatment in patients with Lennox Gastaut syndrome (LGS): 3-year results of an open-label extension (OLE) trial (GWPCARE5). American Academy of Neurology Annual Meeting 2020, Toronto, Ontario, Canada. (canceled due to COVID19 pandemic)
Newell G, Shandley S, Papadelis C, Perry MS. Characteristics of children with epilepsy failing more than 2 AEDs prior to surgical referral. Child Neurology Society Meeting 2020, San Diego, CA.

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