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style="margin-bottom: 30px;"><img src="/siteassets/images/research/drhuang-25.jpg" alt="Dr. Clifton Huang with patient" width="1105" height="545"></p> <p>Cook Children's has awarded Clifton Huang, M.D., an Endowed Chair to create a Center of Excellence in Advanced Endoscopy and Confocal Laser Endomicroscopy (CLE), and put Cook Children's at the forefront of live gastrointestinal endoscopic diagnosis, therapeutics and molecular imaging. This will enhance the management of multiple acute and chronic gastrointestinal disorders in an expedient and more precise way. The ultimate goal is to develop live diagnostic criteria using CLE technology that can be validated with conventional histology for mutiple gastrointestinal conditions. <span data-teams="true">Immunosuppression therapy is frequently used for treating moderate to severe Inflammatory Bowel Disease (IBD). However, it carries significant risks and high treatment failure. Over 50% of patients will have either primary or secondary therapy failure within the first year. CLE will be a ground-breaking approach pioneering new endoscopic criteria to diagnose IBD, evaluate remission, and guide personalized treatment. This could result in reducing loss of response to under 15%, transforming IBD care. Simultaneously, the restructured IBD program aspires to establish Cook Children's as a benchmark institution, increasing steroid-free remission rates above 85%, surpassing the national average of 82% from the current 70%. These initiatives will position Cook Children's as a leader in the precise and effective management of IBD.</span></p></div> </div> <div class="youtube-wrapper mt-6"> <div class="youtube score-video score-youtube-video" tabindex="0"> <img class="youtube-thumbnail" src="https://img.youtube.com/vi/TJ0xAW7xL_w/maxresdefault.jpg"> <div data-react-component="Analytics" data-props='{"event":"VideoClicked","properties":{"source":"https://www.cookchildrens.org/services/research/endowed-chair-program/confocal-laser-endomicroscopy/","videoURL":"https://www.youtube.com/watch?v=TJ0xAW7xL_w"}}'></div> <div class="youtube-iframe" id="ytplayer-TJ0xAW7xL_w" data-id="TJ0xAW7xL_w"></div> </div> </div> <div class="section-hero-block image mt-6 " style="background-color: #F2F4F5;"> <div class="page-layout"> <img src="/siteassets/images/physicianbios/sq/clifton-huang.jpg" alt="clifton-huang" title="clifton-huang" /> </div> <div class="page-layout"> <div class="score-section-hero"> <h2> Meet Dr. Huang </h2> <div class="score-hero-body rich-text"> <div class="rich-text"><p>Dr. Huang is passionate about helping children with IBD find relief for their chronic gastric conditions, so they can get back to being kids.</p></div> </div> <div class="score-call-to-action"> <a class="score-button GTMBUTTON secondary" target="_self" rel="" title="View bio" href="https://www.cookchildrens.org/doctors/gastroenterology/dr-clifton-huang/" > View bio <svg class='arrow-forward' width="14" height="14" viewBox="0 0 14 14" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6.41683 13.0833C6.26405 12.9306 6.18405 12.7361 6.17683 12.5C6.17016 12.2639 6.24322 12.0694 6.396 11.9167L10.4793 7.83333H1.16683C0.930718 7.83333 0.732663 7.75333 0.572663 7.59333C0.413218 7.43389 0.333496 7.23611 0.333496 7C0.333496 6.76389 0.413218 6.56583 0.572663 6.40583C0.732663 6.24639 0.930718 6.16667 1.16683 6.16667H10.4793L6.396 2.08333C6.24322 1.93056 6.17016 1.73611 6.17683 1.5C6.18405 1.26389 6.26405 1.06944 6.41683 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0.413218 6.56583 0.572663 6.40583C0.732663 6.24639 0.930718 6.16667 1.16683 6.16667H10.4793L6.396 2.08333C6.24322 1.93056 6.17016 1.73611 6.17683 1.5C6.18405 1.26389 6.26405 1.06944 6.41683 0.916666C6.56961 0.763889 6.76405 0.6875 7.00016 0.6875C7.23627 0.6875 7.43072 0.763889 7.5835 0.916666L13.0835 6.41667C13.1668 6.48611 13.226 6.57278 13.261 6.67667C13.2954 6.78111 13.3127 6.88889 13.3127 7C13.3127 7.11111 13.2954 7.21528 13.261 7.3125C13.226 7.40972 13.1668 7.5 13.0835 7.58333L7.5835 13.0833C7.43072 13.2361 7.23627 13.3125 7.00016 13.3125C6.76405 13.3125 6.56961 13.2361 6.41683 13.0833Z" /> </svg> </a> </div> </div> </div> </div> <div class="score-accordion mt-6" id="597f3959-131b-4187-b0c4-a47cfdf6e49f"> <div class="score-accordion-panel "> <div class="panel-heading"> <h3 id="0619d293-cc8e-4ab3-be6f-a1d087607452-title" class="panel-title"> <button type="button" class="accordion-button GTMBUTTON" data-target="#0619d293-cc8e-4ab3-be6f-a1d087607452-panel" aria-expanded="false" aria-controls="0619d293-cc8e-4ab3-be6f-a1d087607452-panel"> Key studies and activities </button> </h3> </div> <div id="0619d293-cc8e-4ab3-be6f-a1d087607452-panel" class="panel-collapse collapse "> <div class="panel-body"> <div class="rich-text"> <h4> </h4> <div class="rich-text"><h3>Internal Review Board studies</h3> <ul> <li>A single-center study to evaluate mucosal disease activity in pediatric patients with inflammatory bowel disease comparing confocal laser endomicroscopy-based images to endoscopy, histology and clinical disease activity</li> <li>A retrospective review of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography outcomes in pediatric patients</li> <li>A single-center study to evaluate the utility of Confocal Laser Endomicroscopy in gastrointestinal disorders excluding inflammatory bowel disease</li> <li>Endoscopic Ultrasound (EUS) Research Registry: A multicenter ambispective cohort study</li> </ul> <p><a class="btn btn-activity score-button secondary" title="Gastroenterology research" href="/services/research/active-research/?ctg=Gastroenterology">Gastroenterology research</a></p></div> </div> </div> </div> </div> <div class="score-accordion-panel "> <div class="panel-heading"> <h3 id="48dbdbdb-9526-4e09-a6b9-e660b3f44bff-title" class="panel-title"> <button type="button" class="accordion-button GTMBUTTON" data-target="#48dbdbdb-9526-4e09-a6b9-e660b3f44bff-panel" aria-expanded="false" aria-controls="48dbdbdb-9526-4e09-a6b9-e660b3f44bff-panel"> Grants and awards </button> </h3> </div> <div id="48dbdbdb-9526-4e09-a6b9-e660b3f44bff-panel" class="panel-collapse collapse "> <div class="panel-body"> <div class="rich-text"> <h4> </h4> <div class="rich-text"><p>2020 Cook Children’s Foundation Endowed Chair Recipient </p> <p>2022 Best Abstract Oral Presentation: Atypical Food Allergies in Pediatric Patients Diagnosed by Confocal Laser Endomicroscopy</p></div> </div> </div> </div> </div> <div class="score-accordion-panel "> <div class="panel-heading"> <h3 id="f9a83f76-566d-4652-b4bf-043b43123c9b-title" class="panel-title"> <button type="button" class="accordion-button GTMBUTTON" data-target="#f9a83f76-566d-4652-b4bf-043b43123c9b-panel" aria-expanded="false" aria-controls="f9a83f76-566d-4652-b4bf-043b43123c9b-panel"> Publications and presentations </button> </h3> </div> <div id="f9a83f76-566d-4652-b4bf-043b43123c9b-panel" class="panel-collapse collapse "> <div class="panel-body"> <div class="rich-text"> <h4> </h4> <div class="rich-text"><h3>Peer-reviewed articles</h3> <ul> <li>Lerner, Diana G et al. “Advances in Pediatric Diagnostic Endoscopy: A State-of-the-Art Review.” <em>JPGN reports</em> 3,3 e224. 29 Jul. <strong>2022</strong>, doi:10.1097/PG9.0000000000000224</li> <li>Liu, Quin Y et al. “Predictors of Prolonged Fluoroscopy Exposure in Pediatric Endoscopic Retrograde Cholangiopancreatography: Results From the Large Pediatric Endoscopic Retrograde Cholangiopancreatography Database Initiative Multicenter Cohort.” <em>Journal of pediatric gastroenterology and nutrition</em> 74,3 <strong>(2022)</strong>: 408-412. doi:10.1097/MPG.0000000000003347</li> <li>Troendle, David M et al. “Technical Outcomes in Pediatric Endoscopic Retrograde Cholangiopancreatography: Data from an International Collaborative.” <em>Journal of pediatric </em><em style="font-family: gibson-book; font-size: 1.25rem; letter-spacing: 0px;">gastroenterology and nutrition</em><span style="font-family: gibson-book; font-size: 1.25rem; letter-spacing: 0px;"> vol. 75,6 </span><strong style="font-family: gibson-book; font-size: 1.25rem; letter-spacing: 0px;">(2022)</strong><span style="font-family: gibson-book; font-size: 1.25rem; letter-spacing: 0px;">: 755-760. doi:10.1097/MPG.0000000000003612</span></li> </ul> <ul> <li>Gupta, Rekha et al. “Impact of Trainee Involvement on Pediatric ERCP Procedures: Results From the Pediatric ERCP Initiative.” <em>Journal of pediatric gastroenterology and nutrition</em> 77,1 <strong>(2023)</strong>: 126-130. doi:10.1097/MPG.0000000000003782</li> <li>Trocchia, Carolena et al. “Pediatric ERCP in the Setting of Acute Pancreatitis: A Secondary Analysis of an International Multicenter Cohort Study.” <em>Journal of pediatric gastroenterology and nutrition</em> 76,6 <strong>(2023):</strong> 817-821. doi:10.1097/MPG.0000000000003762</li> <li>Balsiger LM, Rusticeanu M, Langhorst J, Sina C, Benamouzig R, Huang C, Tack J, Kiesslich R. Review<strong> (2024)</strong>: Food-induced mucosal alterations visualized using endomicroscopy. Neurogastroenterol Motil. 2024 Sep 24:e14930. doi: 10.1111/nmo.14930. Epub ahead of print. PMID: 39314095</li> </ul> <h3>Chapters in books</h3> <ul> <li>Huang C, Kugathasan S. Effect of Age at Onset on the IBD Phenotypes and Genotypes. Book chapter published November 2011, ISBN 978-1-60795-034-9.</li> <li>Huang C, Kugathasan S. Markers that Differentiate Early from Late IBD. Book chapter published 2011-2012. PMID: 22796800.</li> </ul> <h3>Presentations</h3> <ul> <li>The Role of Endoscopic Retrograde Cholangiopancreatography in Biliary and Pancreatic Injuries. Mira Sankhavaram, Sumith Roy, Clifton Huang. <strong>Presented at Digestive Disease Week 2024 (Washington, D.C.)</strong></li> <li>Confocal Laser Endomicroscopy with Food Allergy Sensitivity Testing to Detect Atypical Food Allergies in Pediatric Patients with Chronic Abdominal Pain and Irritable Bowel Syndrome. Clifton Huang, Sumith Roy, Rachel Rice, James Marshall. <strong>Presented at Digestive Disease Week 2024. (Washington, D.C.)</strong></li> <li>Endoscopic Ultrasound guided Liver Biopsy in Pediatric Patients. Sumith Roy, Clifton Huang<sup>. </sup><strong>Presented at North American Society for Pediatric Gastroenterology, Hepatology and Nutrition 2024</strong>. <strong>(Hollywood, FL)</strong></li> <li>Endoscopic Ultrasound in the Management of Pediatric Gastrointestinal Diseases Sumith Roy, Clifton Huang. <strong>Presented at 7th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition 2024. (Buenos Aires, Argentina)</strong></li> <li>Confocal Laser Endomicroscopy may Predict Disease Activity in Pediatric Patients with Inflammatory Bowel Disease. Sumith Roy ,Sandy Cope-Yokoyama ,Clifton Huang.<strong> Presented at 7th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition 2024. (Buenos Aires, Argentina)</strong></li> </ul></div> </div> </div> </div> </div> <div class="score-accordion-panel "> <div class="panel-heading"> <h3 id="0717794a-14d6-4c88-8eed-acebd7520c0b-title" class="panel-title"> <button type="button" class="accordion-button GTMBUTTON" data-target="#0717794a-14d6-4c88-8eed-acebd7520c0b-panel" aria-expanded="false" aria-controls="0717794a-14d6-4c88-8eed-acebd7520c0b-panel"> Presentations </button> </h3> </div> <div id="0717794a-14d6-4c88-8eed-acebd7520c0b-panel" class="panel-collapse collapse "> <div class="panel-body"> <div class="rich-text"> <h4> </h4> <div class="rich-text"><p>2024</p> <ol> <li>The Role of Endoscopic Retrograde Cholangiopancreatography in Biliary and Pancreatic Injuries. Mira Sankhavaram, Sumith Roy, Clifton Huang. <strong>Presented at Digestive Disease Week 2024.</strong></li> <li>Confocal Laser Endomicroscopy with Food Allergy Sensitivity Testing to Detect Atypical Food Allergies in Pediatric Patients with Chronic Abdominal Pain and Irritable Bowel Syndrome. Clifton Huang, Sumith Roy, Rachel Rice, James Marshall. <strong>Presented at Digestive Disease Week 2024.</strong></li> <li>Endoscopic Ultrasound guided Liver Biopsy in Pediatric Patients. Sumith Roy, Clifton Huang<sup>. </sup><strong>Presented at North American Society for Pediatric Gastroenterology, Hepatology and Nutrition 2024</strong>.</li> <li>Endoscopic Ultrasound in the Management of Pediatric Gastrointestinal Diseases Sumith Roy, Clifton Huang. <strong>Presented at 7th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition 2024.</strong></li> <li>Confocal Laser Endomicroscopy may Predict Disease Activity in Pediatric Patients with Inflammatory Bowel Disease. Sumith Roy ,Sandy Cope-Yokoyama ,Clifton Huang.<strong> Presented at 7th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition 2024.</strong></li> </ol></div> </div> </div> </div> </div> </div> <div class="rte-content"> <div class="rich-text"><h2 style="margin-top: -30px;">Meet our researchers</h2> <div class="section-hero-narrow"> <div class="row bg-lightgrey"> <div class="w-3col"><img src="/siteassets/images/research/sumith-roy.jpg" alt="Sumith Roy, MBBS, MPH, Research Scientist" width="168" height="168"></div> <div class="w-9col"> <h4>Sumith Roy, MBBS, MPH, Research Scientist</h4> <p>Sumith is a research scientist actively involved in the life cycle of investigator-initiated studies involving advanced endoscopic procedures in Gastroenterology. She joined Cook Children's Health Care System in 2022. She is a physician by training and received a Master of Public Health with a focus in Epidemiology from New York Medical College, NY. She is also a doctoral candidate, at Columbia University, Mailman School of Public Health where she previously worked as a Research Scientist on a longitudinal cohort study investigating the association of periodontal microbiota, inflammatory phenotypes and insulin resistance among diabetes-free adults.</p> <p><a class="btn btn-activity score-button secondary" title="sumith.roy@cookchildrens.org" href="mailto:sumith.roy@cookchildrens.org">sumith.roy@cookchildrens.org</a></p> </div> </div> </div> <h2>Physicians interested in training?</h2> <p>Contact: <a title="Clifton Huang" href="mailto:clifton.huang@cookchildrens.org">Clifton Huang, M.D.</a></p> <h2>Support this research</h2> <p>Be part of the innovative and life-changing work we're doing at Cook Children's. Support the Endowed Chair Program today.</p> <p><a class="btn btn-activity score-button secondary" title="Donate now" href="https://foundation.cookchildrens.org/site/Donation2?4020.donation=form1&df_id=4020&_gl=1*1jgjp6d*_gcl_au*MTU3MjU5MDQzOS4xNzMzMTU2ODA4" target="_blank" rel="noopener">Donate now</a></p></div> </div> </div> </div> </div> <div class="right-content-bottom pt-4"> <section class="score-stripe " style="" data-epi-type="content"> <div class="container"> <div class="w-full"> <div class="content-area"> <div class=" page-layout"> <div class="rich-text "> <div class="rich-text"><p><a title="Give to research" href="https://foundation.cookchildrens.org/site/Donation2?4020.donation=form1&df_id=4020&_gl=1*1jgjp6d*_gcl_au*MTU3MjU5MDQzOS4xNzMzMTU2ODA4" target=" _blank"><img src="/siteassets/images/professionals/professionals/chair/endowed_chair_right_rail.png" alt="Illustration of researcher using microscope" width="614" height="795"></a></p></div> </div> </div> </div> </div> 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