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<div class="interior-page"> <div class="top-content-wrapper"> <div class="content-wrapper"> <div class="document-header"> <h1 data-epi-type="title">Endowed Chair: Lennox-Gastaut Comprehensive Care Center led by Cynthia Keator, M.D.</h1> </div> <div class="content-area" data-epi-type="content"> <div class="right-content"> <div class="score-accordion section-menu-wrapper"> <div class="score-accordion-panel"> <div class="panel-heading"> <div class="panel-title"> <button type="button" class="accordion-button" data-target="#sectionMenu" aria-expanded="false" aria-controls="accordion1"> In This Section </button> </div> </div><div id="sectionMenu" class="panel-collapse collapse"> <div class="panel-body"> <div class="bg-lightgrey"> <ul class="main"> <li class="section-menu-item "> <a href="/services/research/" aria-label="Research" class="GTMMENU" target="_self"> Research </a> </li> </ul> <ul class="level-1"> <li class="section-menu-item "> <a 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<li class="section-menu-item "> <a href="/services/research/participating-in-research/" aria-label="Participating in Research" class="GTMMENU" target="_self"> Participating in Research </a> </li> </ul> </div> </div> </div> </div> </div> <div class="right-content-top"> <section class="score-stripe " style="" data-epi-type="content"> <div class="container"> <div class="w-full"> <div class="content-area"> <div class=" page-layout"> <div class="rich-text "> <div class="rich-text"><p><a title="Give to research" href="https://foundation.cookchildrens.org/site/Donation2?4020.donation=form1&df_id=4020&_gl=1*1jgjp6d*_gcl_au*MTU3MjU5MDQzOS4xNzMzMTU2ODA4" target=" _blank"><img src="/siteassets/images/professionals/professionals/chair/endowed_chair_right_rail.png" alt="Illustration of researcher using microscope" width="614" height="795"></a></p></div> </div> </div> </div> </div> </div> </section> </div> </div> <div class="top-content"> <div class="rte-content"> <div class="rich-text"><p style="margin-bottom: 30px;"><img src="/siteassets/images/research/photo-keator-endowed-chair.jpg" alt="Dr. Keator with patient" width="1105" height="545"></p> <p>Cook Children's has awarded Cynthia Keator, M.D., an Endowed Chair to establish a new standard of care for patients with Lennox-Gastaut syndrome (LGS), a rare, severe form of epilepsy that typically begins in childhood. This type of epilepsy causes frequent seizures that are difficult to control with medication. Dr. Keator and her comprehensive clinical team collect data, monitor patients and identify patterns that enable the early identification of high-risk patients before LGS onset. This proactive approach allows for evaluation and intervention before the syndrome develops. The program aims to establish the natural history of LGS, identify biomarkers and create best practices for treatment. It also will be the first program in the country to comprehensively target LGS, making a dramatic, meaningful impact on this devastating condition.</p></div> </div> <div class="youtube-wrapper mt-6"> <div class="youtube score-video score-youtube-video" tabindex="0"> <img class="youtube-thumbnail" src="https://img.youtube.com/vi/zpuIfy9Oy-s/maxresdefault.jpg"> <div data-react-component="Analytics" data-props='{"event":"VideoClicked","properties":{"source":"https://www.cookchildrens.org/services/research/endowed-chair-program/lennox-gastaut-center/","videoURL":"https://www.youtube.com/watch?v=zpuIfy9Oy-s"}}'></div> <div class="youtube-iframe" id="ytplayer-zpuIfy9Oy-s" data-id="zpuIfy9Oy-s"></div> </div> </div> <div class="section-hero-block image mt-6 " style="background-color: #F2F4F5;"> <div class="page-layout"> <img src="/siteassets/images/physicianbios/cynthia-keator.jpg" alt="cynthia-keator" title="cynthia-keator" /> </div> <div class="page-layout"> <div class="score-section-hero"> <h2> Meet Dr. Keator </h2> <div class="score-hero-body rich-text"> <div class="rich-text"><p>Dr. Keator has dedicated her career to guiding families of children with epilepsy, and discovering effective treatments that can assist in improving their quality of life.</p></div> </div> <div class="score-call-to-action"> <a class="score-button GTMBUTTON secondary" target="_self" rel="" title="View bio" href="https://www.cookchildrens.org/doctors/neurosciences/dr-cynthia-guadalupe-keator/" > View bio <svg class='arrow-forward' width="14" height="14" viewBox="0 0 14 14" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6.41683 13.0833C6.26405 12.9306 6.18405 12.7361 6.17683 12.5C6.17016 12.2639 6.24322 12.0694 6.396 11.9167L10.4793 7.83333H1.16683C0.930718 7.83333 0.732663 7.75333 0.572663 7.59333C0.413218 7.43389 0.333496 7.23611 0.333496 7C0.333496 6.76389 0.413218 6.56583 0.572663 6.40583C0.732663 6.24639 0.930718 6.16667 1.16683 6.16667H10.4793L6.396 2.08333C6.24322 1.93056 6.17016 1.73611 6.17683 1.5C6.18405 1.26389 6.26405 1.06944 6.41683 0.916666C6.56961 0.763889 6.76405 0.6875 7.00016 0.6875C7.23627 0.6875 7.43072 0.763889 7.5835 0.916666L13.0835 6.41667C13.1668 6.48611 13.226 6.57278 13.261 6.67667C13.2954 6.78111 13.3127 6.88889 13.3127 7C13.3127 7.11111 13.2954 7.21528 13.261 7.3125C13.226 7.40972 13.1668 7.5 13.0835 7.58333L7.5835 13.0833C7.43072 13.2361 7.23627 13.3125 7.00016 13.3125C6.76405 13.3125 6.56961 13.2361 6.41683 13.0833Z" /> </svg> </a> <a class="score-button GTMBUTTON secondary" target="_self" rel="" title="About Comprehensive Epilepsy Program" href="https://www.cookchildrens.org/services/neurosciences/clinics/comprehensive-epilepsy-program/?ctg=Neurosciences" > About Comprehensive Epilepsy Program <svg class='arrow-forward' width="14" height="14" viewBox="0 0 14 14" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6.41683 13.0833C6.26405 12.9306 6.18405 12.7361 6.17683 12.5C6.17016 12.2639 6.24322 12.0694 6.396 11.9167L10.4793 7.83333H1.16683C0.930718 7.83333 0.732663 7.75333 0.572663 7.59333C0.413218 7.43389 0.333496 7.23611 0.333496 7C0.333496 6.76389 0.413218 6.56583 0.572663 6.40583C0.732663 6.24639 0.930718 6.16667 1.16683 6.16667H10.4793L6.396 2.08333C6.24322 1.93056 6.17016 1.73611 6.17683 1.5C6.18405 1.26389 6.26405 1.06944 6.41683 0.916666C6.56961 0.763889 6.76405 0.6875 7.00016 0.6875C7.23627 0.6875 7.43072 0.763889 7.5835 0.916666L13.0835 6.41667C13.1668 6.48611 13.226 6.57278 13.261 6.67667C13.2954 6.78111 13.3127 6.88889 13.3127 7C13.3127 7.11111 13.2954 7.21528 13.261 7.3125C13.226 7.40972 13.1668 7.5 13.0835 7.58333L7.5835 13.0833C7.43072 13.2361 7.23627 13.3125 7.00016 13.3125C6.76405 13.3125 6.56961 13.2361 6.41683 13.0833Z" /> </svg> </a> </div> </div> </div> </div> <div class="score-accordion mt-6" id="6eea0b2e-7fee-4c99-a68a-6a58a2576469"> <div class="score-accordion-panel "> <div class="panel-heading"> <h3 id="bb768bd9-d862-4919-93f8-7d99807b65c2-title" class="panel-title"> <button type="button" class="accordion-button GTMBUTTON" data-target="#bb768bd9-d862-4919-93f8-7d99807b65c2-panel" aria-expanded="false" aria-controls="bb768bd9-d862-4919-93f8-7d99807b65c2-panel"> Key studies and activities </button> </h3> </div> <div id="bb768bd9-d862-4919-93f8-7d99807b65c2-panel" class="panel-collapse collapse "> <div class="panel-body"> <div class="rich-text"> <h4> </h4> <div class="rich-text"><p><a class="btn btn-activity score-button secondary" title="Other Neurosciences research" href="/services/research/active-research/?ctg=Neurosciences">Neurosciences research</a></p></div> </div> </div> </div> </div> <div class="score-accordion-panel "> <div class="panel-heading"> <h3 id="8bb850bf-3396-4ced-b490-7877e1cc3f19-title" class="panel-title"> <button type="button" class="accordion-button GTMBUTTON" data-target="#8bb850bf-3396-4ced-b490-7877e1cc3f19-panel" aria-expanded="false" aria-controls="8bb850bf-3396-4ced-b490-7877e1cc3f19-panel"> Publications and presentations </button> </h3> </div> <div id="8bb850bf-3396-4ced-b490-7877e1cc3f19-panel" class="panel-collapse collapse "> <div class="panel-body"> <div class="rich-text"> <h4> </h4> <div class="rich-text"><p>Neuromodulation Strategies in Lennox-Gastaut Syndrome: Practical Clinical Guidance from the Pediatric Epilepsy Research Consortium. Samanta D, Augaroon G, Fine A, Karakas C, Chiu M, Jain P, Seinfeld S, Knowles J, Mohamed I, Stafstrom C, Dixon-Salazar T, Patel A, Bhalla S, Keator C, Vidaurre J, Warren A, Shellhaas R, Perry M. Epilepsy Research, 201 (2025).</p></div> </div> </div> </div> </div> </div> <div class="rte-content"> <div class="rich-text"><h2 style="margin-top: -30px;">Meet our researchers</h2> <div class="section-hero-narrow"> <div class="row bg-lightgrey"> <div class="w-3col"><img src="/siteassets/images/research/christopher-hagen.jpg" alt="Christopher Hagen" width="168" height="235"></div> <div class="w-9col"> <h4>Christopher Hagen, Ph.D., Research Scientist</h4> <p>Originally from Austin, TX, I received my master's degree in Biology and my Ph.D. in Experimental Psychology from Texas Christian University, where my focus was in behavioral neuroscience. During my master's research, I investigated how different environmental factors affect learning, memory, and Alzheimer's pathologies. Transitioning into my doctoral research, my projects explored the brain's response to negative emotions like depression, frustration, and loss. I was specifically interested in how different neural circuits within a set of brain areas known as the basal ganglia contribute to both the onset of and recovery from these emotions. After receiving my Ph.D., I began working at Cook Children's as a Research Scientist in neurology, where our research aims to identify novel biomarkers of Lennox-Gastaut syndrome. In my free time, I enjoy traveling with my partner, playing board games, and going to the symphony.</p> </div> </div> </div> <h2>Related information</h2> <ul> <li><a title="Pediatric palliative epilepsy neurosurgery" href="/health-resources/doc-talk/pediatric-palliative-epilepsy-neurosurgery--giving-kids-a-brighter-quality-of-life/">Pediatric palliative epilepsy neurosurgery - giving kids a brighter quality of life</a></li> <li><a title="Brain Stimulation" href="https://www.checkupnewsroom.com/brain-stimulation-curbs-teens-worst-seizures/" target="_blank" rel="noopener">Brain Stimulation Curbs Teen's Worst Seizures</a></li> <li><a title="Teen with Epilepsy" href="https://www.checkupnewsroom.com/teen-with-epilepsy-shows-reduction-in-seizures-after-palliative-surgery/" target="_blank" rel="noopener">Teen with Epilepsy Shows Reduction in Seizures After Palliative Surgery</a></li> <li><a title="Prosper Adds Seizure Care Service" href="https://www.checkupnewsroom.com/cook-childrens-medical-center--prosper-adds-seizure-care-service/" target="_blank" rel="noopener">Cook Children's Medical Center - Prosper Adds Seizure Care Service</a></li> <li><a title="Teen Seizure Free" href="https://www.checkupnewsroom.com/teen-seizure-free-for-the-first-time-in-16-years-following-brain-surgery/" target="_blank" rel="noopener">Teen Seizure Free For The First Time in 16 Years Following Brain Surgery</a></li> <li><a title="First in North Texas" href="https://www.checkupnewsroom.com/cook-childrens-patient-becomes-first-in-north-texas-implanted-with-smart-device--to-control-seizures/" target="_blank" rel="noopener">Cook Children's Patient Becomes First in North Texas Implanted With Smart Device to Control Seizures</a></li> <li><a title="First Patient in Trailblazing Endoscopic Surgery" href="https://www.checkupnewsroom.com/the-pioneer-child-becomes-first-patient-in-trailblazing-surgery-that-disconnects-part-of-his-brain-to-stop-daily-seizures/" target="_blank" rel="noopener">The Pioneer: Child Becomes First Patient in Trailblazing Endoscopic Surgery that Disconnects Part of His Brain to Stop Daily Seizures</a></li> <li><a title="Totally surreal" href="https://www.checkupnewsroom.com/totally-surreal---from-volunteer-to-neurologist/" target="_blank" rel="noopener">'Totally surreal.' A Cook Children's neurologist looks back on her days as a volunteer</a></li> </ul> <h2>Support this research</h2> <p>Be part of the innovative and life-changing work we’re doing at Cook Children's. Support the Endowed Chair Program today.</p> <p><a class="btn btn-activity score-button secondary" title="Donate now" href="https://foundation.cookchildrens.org/site/Donation2?4020.donation=form1&df_id=4020&_gl=1*1jgjp6d*_gcl_au*MTU3MjU5MDQzOS4xNzMzMTU2ODA4" target="_blank" rel="noopener">Donate now</a></p></div> </div> </div> </div> </div> <div class="right-content-bottom pt-4"> <section class="score-stripe " style="" data-epi-type="content"> <div class="container"> <div class="w-full"> <div class="content-area"> <div class=" page-layout"> <div class="rich-text "> <div class="rich-text"><p><a title="Give to research" href="https://foundation.cookchildrens.org/site/Donation2?4020.donation=form1&df_id=4020&_gl=1*1jgjp6d*_gcl_au*MTU3MjU5MDQzOS4xNzMzMTU2ODA4" target=" _blank"><img src="/siteassets/images/professionals/professionals/chair/endowed_chair_right_rail.png" alt="Illustration of researcher using microscope" width="614" height="795"></a></p></div> </div> </div> </div> </div> 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