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<div class="interior-page"> <div class="top-content-wrapper"> <div class="content-wrapper"> <div class="document-header"> <h1 data-epi-type="title">Endowed Chair: Focused Ultrasound Program led by Sibo Zhao, M.D.</h1> </div> <div class="content-area" data-epi-type="content"> <div class="right-content"> <div class="score-accordion section-menu-wrapper"> <div class="score-accordion-panel"> <div class="panel-heading"> <div class="panel-title"> <button type="button" class="accordion-button" data-target="#sectionMenu" aria-expanded="false" aria-controls="accordion1"> In This Section </button> </div> </div><div id="sectionMenu" class="panel-collapse collapse"> <div class="panel-body"> <div class="bg-lightgrey"> <ul class="main"> <li class="section-menu-item "> <a href="/services/research/" aria-label="Research" class="GTMMENU" target="_self"> Research </a> </li> </ul> <ul class="level-1"> <li class="section-menu-item "> <a href="/services/research/research-administration-office/" 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href="/services/research/participating-in-research/" aria-label="Participating in Research" class="GTMMENU" target="_self"> Participating in Research </a> </li> </ul> </div> </div> </div> </div> </div> <div class="right-content-top"> <section class="score-stripe " style="" data-epi-type="content"> <div class="container"> <div class="w-full"> <div class="content-area"> <div class=" page-layout"> <div class="rich-text "> <div class="rich-text"><p><a title="Give to research" href="https://foundation.cookchildrens.org/site/Donation2?4020.donation=form1&df_id=4020&_gl=1*1jgjp6d*_gcl_au*MTU3MjU5MDQzOS4xNzMzMTU2ODA4" target=" _blank"><img src="/siteassets/images/professionals/professionals/chair/endowed_chair_right_rail.png" alt="Illustration of researcher using microscope" width="614" height="795"></a></p></div> </div> </div> </div> </div> </div> </section> </div> </div> <div class="top-content"> <div class="rte-content"> <div class="rich-text"><p style="margin-bottom: 30px;"><img src="/siteassets/images/research/sibo-zhao-endowed-25.jpg" alt="Neuro-oncologist and Endowed Chair Sibo Zhao, M.D., interacts with patient in clinic" width="1105" height="545"></p> <p>Cook Children's has awarded Sibo Zhao, M.D., an Endowed Chair to start a focused ultrasound program and develop novel therapies for the treatment of tumors and other potential future uses. Focused ultrasound involves concentrating sound waves or ultrasonic energy to a targeted area in the body. This non-invasive, incisionless treatment has multiple uses including; thermal ablation (heating tissue to treat tumors), opening the blood-brain barrier (to make drugs more effective in the brain) and neuromodulation (stimulating or blocking neural activity without damaging tissue). Although the overall survival rates for pediatric cancer have improved over the last several decades, there are still many patients with certain types of brain cancer diagnoses that have poor outcomes and limited treatment options. Cook Children's will be the first pediatric medical center in Texas to offer focused ultrasound therapy. Our patients and their families often must make the difficult decision of traveling to other states to participate in clinical trials, but the focused ultrasound program at Cook Children's will give patients and families the opportunity to stay local. Our innovative program will establish Cook Children's at the forefront of Neuro-oncology care across the nation.</p></div> </div> <div class="youtube-wrapper mt-6"> <div class="youtube score-video score-youtube-video" tabindex="0"> <img class="youtube-thumbnail" src="https://img.youtube.com/vi/5QuPG6Mq0KI/maxresdefault.jpg"> <div data-react-component="Analytics" data-props='{"event":"VideoClicked","properties":{"source":"https://www.cookchildrens.org/services/research/endowed-chair-program/focused-ultrasound/","videoURL":"https://www.youtube.com/watch?v=5QuPG6Mq0KI"}}'></div> <div class="youtube-iframe" id="ytplayer-5QuPG6Mq0KI" data-id="5QuPG6Mq0KI"></div> </div> </div> <div class="section-hero-block image mt-6 " style="background-color: #F2F4F5;"> <div class="page-layout"> <img src="/siteassets/images/physicianbios/sibo-zhao.jpg" alt="sibo-zhao" title="sibo-zhao" /> </div> <div class="page-layout"> <div class="score-section-hero"> <h2> Meet Dr. Zhao </h2> <div class="score-hero-body rich-text"> <div class="rich-text"><p>Dr. Zhao is dedicated to helping families of children with brain and spinal tumors, find innovative treatment options that will improve their quality of life - so they can focus on having the best childhood possible.</p></div> </div> <div class="score-call-to-action"> <a class="score-button GTMBUTTON secondary" target="_self" rel="" title="View bio" href="https://www.cookchildrens.org/doctors/neuro-oncology/dr-sibo-zhao/" > View bio <svg class='arrow-forward' width="14" height="14" viewBox="0 0 14 14" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6.41683 13.0833C6.26405 12.9306 6.18405 12.7361 6.17683 12.5C6.17016 12.2639 6.24322 12.0694 6.396 11.9167L10.4793 7.83333H1.16683C0.930718 7.83333 0.732663 7.75333 0.572663 7.59333C0.413218 7.43389 0.333496 7.23611 0.333496 7C0.333496 6.76389 0.413218 6.56583 0.572663 6.40583C0.732663 6.24639 0.930718 6.16667 1.16683 6.16667H10.4793L6.396 2.08333C6.24322 1.93056 6.17016 1.73611 6.17683 1.5C6.18405 1.26389 6.26405 1.06944 6.41683 0.916666C6.56961 0.763889 6.76405 0.6875 7.00016 0.6875C7.23627 0.6875 7.43072 0.763889 7.5835 0.916666L13.0835 6.41667C13.1668 6.48611 13.226 6.57278 13.261 6.67667C13.2954 6.78111 13.3127 6.88889 13.3127 7C13.3127 7.11111 13.2954 7.21528 13.261 7.3125C13.226 7.40972 13.1668 7.5 13.0835 7.58333L7.5835 13.0833C7.43072 13.2361 7.23627 13.3125 7.00016 13.3125C6.76405 13.3125 6.56961 13.2361 6.41683 13.0833Z" /> </svg> </a> <a class="score-button GTMBUTTON secondary" target="_self" rel="" title="About Neuro-oncology Program" href="https://www.cookchildrens.org/services/neuro-oncology/?ctg=Oncology+-+Neuro-Oncology" > About Neuro-oncology Program <svg class='arrow-forward' width="14" height="14" viewBox="0 0 14 14" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6.41683 13.0833C6.26405 12.9306 6.18405 12.7361 6.17683 12.5C6.17016 12.2639 6.24322 12.0694 6.396 11.9167L10.4793 7.83333H1.16683C0.930718 7.83333 0.732663 7.75333 0.572663 7.59333C0.413218 7.43389 0.333496 7.23611 0.333496 7C0.333496 6.76389 0.413218 6.56583 0.572663 6.40583C0.732663 6.24639 0.930718 6.16667 1.16683 6.16667H10.4793L6.396 2.08333C6.24322 1.93056 6.17016 1.73611 6.17683 1.5C6.18405 1.26389 6.26405 1.06944 6.41683 0.916666C6.56961 0.763889 6.76405 0.6875 7.00016 0.6875C7.23627 0.6875 7.43072 0.763889 7.5835 0.916666L13.0835 6.41667C13.1668 6.48611 13.226 6.57278 13.261 6.67667C13.2954 6.78111 13.3127 6.88889 13.3127 7C13.3127 7.11111 13.2954 7.21528 13.261 7.3125C13.226 7.40972 13.1668 7.5 13.0835 7.58333L7.5835 13.0833C7.43072 13.2361 7.23627 13.3125 7.00016 13.3125C6.76405 13.3125 6.56961 13.2361 6.41683 13.0833Z" /> </svg> </a> </div> </div> </div> </div> <div class="score-accordion mt-6" id="28d17527-b9dd-4652-a2a2-96043618b01e"> <div class="score-accordion-panel "> <div class="panel-heading"> <h3 id="751a4566-9d57-47ac-a34d-a656154d7da6-title" class="panel-title"> <button type="button" class="accordion-button GTMBUTTON" data-target="#751a4566-9d57-47ac-a34d-a656154d7da6-panel" aria-expanded="false" aria-controls="751a4566-9d57-47ac-a34d-a656154d7da6-panel"> Key studies and activities </button> </h3> </div> <div id="751a4566-9d57-47ac-a34d-a656154d7da6-panel" class="panel-collapse collapse "> <div class="panel-body"> <div class="rich-text"> <h4> </h4> <div class="rich-text"><ul> <li><a title="Blood Brain Barrier (BBB) Disruption" href="https://www.clinicaltrials.gov/study/NCT05630209?cond=DIPG&term=Focused%20Ultrasound&rank=1" target="_blank" rel="noopener">Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG (Phase I Clinical Trial: NCT05630209)</a></li> </ul> <ul> <li><a title="International DIPG/DMG Registry" href="https://dipgregistry.org/" target="_blank" rel="noopener">Participating center in the International DIPG/DMG Registry </a></li> </ul> <p><a class="btn btn-activity score-button secondary" title="Oncology research" href="/services/research/active-research/?ctg=Gastroenterology">Oncology research</a></p></div> </div> </div> </div> </div> <div class="score-accordion-panel "> <div class="panel-heading"> <h3 id="41f7ffd8-1460-40d6-99ba-30559ad436d2-title" class="panel-title"> <button type="button" class="accordion-button GTMBUTTON" data-target="#41f7ffd8-1460-40d6-99ba-30559ad436d2-panel" aria-expanded="false" aria-controls="41f7ffd8-1460-40d6-99ba-30559ad436d2-panel"> Publications and presentations </button> </h3> </div> <div id="41f7ffd8-1460-40d6-99ba-30559ad436d2-panel" class="panel-collapse collapse "> <div class="panel-body"> <div class="rich-text"> <h4> </h4> <div class="rich-text"><ul> <li>S Zhao and CE Van Skike. Pioneering Pediatric Care: Updates on the Endowed Chair Program with Focused Ultrasound. Cook Children's Research Symposium, 2025.</li> <li>CE Van Skike, F Mansoori, JD Marshall, S Zhao. Building a Premier DIPG Treatment Center: Bridging Local Insights with International Cosmos Data. Cook Children's Research Symposium.</li> </ul></div> </div> </div> </div> </div> </div> <div class="rte-content"> <div class="rich-text"><h2 style="margin-top: -30px;">Meet our researchers</h2> <div class="section-hero-narrow"> <div class="row bg-lightgrey"> <div class="w-3col"><img src="/siteassets/images/research/candice-van-skike.jpg" alt="Candice Van Skike, Ph.D., research scientist" width="168" height="168"></div> <div class="w-9col"> <h4>Candice Van Skike, Ph.D., Research Scientist</h4> <p>I received my Ph.D. in Behavioral Neuroscience from Baylor University. My graduate research investigated the neurobiological correlates of alcohol use and its impact on memory and motor function throughout different life stages, including adolescence, adulthood, and aging. My research during my NIH T32-funded postdoctoral fellowship at the Barshop Institute of Longevity and Aging Studies focused on the brain's vascular system and its role in age-related cognitive decline during healthy aging and in Alzheimer's disease. I identified a specific pathway, mTOR, which could be targeted to treat age-related cognitive impairment by restoring several different aspects of brain vascular function. After this, I transitioned to clinical research, specializing in data analysis for a medical device company in San Antonio that provides innovative solutions for non-compressible hemorrhage.</p> <p>At Cook Children's, I am a Research Scientist who is partnered with the medical director of neuro-oncology, Dr. Sibo Zhao. Together, our goal is to bring low-intensity focused ultrasound, a cutting-edge non-invasive treatment option, to neuro-oncology patients at Cook Children's. In current neuro-oncology clinical trials, acoustic energy is delivered to a specific location in the brain without damaging the surrounding brain tissue, which can be used to enhance the delivery of therapeutics through targeted drug activation and/or blood-brain barrier opening. Low-intensity focused ultrasound in pediatric neuro-oncology is currently limited to clinical trials and is not an FDA-approved treatment. Please reach out to learn more about the current and upcoming clinical trials with low-intensity focused ultrasound at Cook Children's.</p> <p><a class="btn btn-activity score-button secondary" title="Candice Van Skike, Ph.D., research scientist" href="mailto:candice.vanskike@cookchildrens.org">candice.vanskike@cookchildrens.org</a></p> </div> </div> </div> <h2>Support this research</h2> <p>Be part of the innovative and life-changing work we're doing at Cook Children's. Support the Endowed Chair Program today.</p> <p><a class="btn btn-activity score-button secondary" title="Donate now" href="https://foundation.cookchildrens.org/site/Donation2?4020.donation=form1&df_id=4020&_gl=1*1jgjp6d*_gcl_au*MTU3MjU5MDQzOS4xNzMzMTU2ODA4" target="_blank" rel="noopener">Donate now</a></p></div> </div> </div> </div> </div> <div class="right-content-bottom pt-4"> <section class="score-stripe " style="" data-epi-type="content"> <div class="container"> <div class="w-full"> <div class="content-area"> <div class=" page-layout"> <div class="rich-text "> <div class="rich-text"><p><a title="Give to research" href="https://foundation.cookchildrens.org/site/Donation2?4020.donation=form1&df_id=4020&_gl=1*1jgjp6d*_gcl_au*MTU3MjU5MDQzOS4xNzMzMTU2ODA4" target=" _blank"><img src="/siteassets/images/professionals/professionals/chair/endowed_chair_right_rail.png" alt="Illustration of researcher using microscope" width="614" height="795"></a></p></div> </div> </div> </div> </div> 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