Endowed Chair: Precision Medicine Program led by Anish Ray, M.D.

Endowed Chair Anish Ray, M.D., with a patient

Cook Children's has awarded Anish Ray, M.D., an Endowed Chair to establish the Precision Medicine Program. This transformative program will both expand on our pharmacogenomics and targeted therapeutics expertise in oncology and create a precision medicine service infrastructure to optimize diagnosis and targeted treatments across specialties. It will empower clinicians and families alike to embrace individualized health management through precision health equity. The program will also accelerate precision research efforts, advancing our ability to provide tailored care, decreasing time to diagnosis, and improving outcomes. The Cook Children's Precision Medicine Program will pioneer individualized therapies that dramatically improve the lives of every child with a genetic basis for illness.

Meet Dr. Ray

Dr. Ray is passionate about elevating the standard of care for personalized pediatric cancer treatment by advancing research, targeted therapy and data driven treatment plans.

View bio About Pediatric Precision Medicine

Targeted approach to Langerhans Cell Histiocytosis (LCH) using MEK inhibitor, Trametinib: https://www.clinicaltrials.gov/study/NCT06582745?intr=trametinib&rank=9
Precision Medicine Registry
N Lorem: Development of personalized antisense oligonucleotides for patients with nano-rare diseases

Oncology

Hematology

Peer Reviewed Articles

Kumar, S., Gonzalez, A., Farbo, D., Albritton, K., Ray, A. “The effects of proton and photon radiation therapy on the development of pediatric dermatitis”. Radiation, November, 2024.
Ray, A., Levitt, M., Efunkoya T., Trinkman H. “Precision Medicine in Acute Lymphoblastic leukemia”. Children, November, 2024. https://doi.org/10.20944/preprints202410.0191.v1
Zumwalt, L., Schluterman H., Ray, A. “Role of medical students in a pediatric oncology precision medicine clinic”. BMC Medical Education, December, 2024.
Zumwalt, L., Schluterman H., Ray, A. “Life-threatening lymphatic malformation with somatic activating NRAS mutation successfully treated with trametinib: a case study”. Journal of Pediatric Hematology/Oncology, January, 2025.
Wojciechowska N, Orr K, Ray A. Immune Checkpoint Inhibition in Pediatric Oncology Patients: A Single-Institution Experience. Hemato 2024; 5(1): 66-80
Wojciechowska N, Burke S, Ray A. “MEK Inhibition in the Treatment of Congenital Langerhans Cell Histiocytosis: A Case Report and Review of the Literature” J Pediatr Hematol Oncol 2024;46:383–387
L Hamilton, DP Wilson. Principles of Genetic Testing for Dyslipidemia in Children. Endotext, 2024.
R Lokkesmoe, L Hamilton. The role of reverse cascade screening in children with familial hypercholesterolemia: A literature review and analysis. Current Atherosclerosis Reports, 2024.

Poster Presentations

A Ray, H Trinkman, D Carrasco, L Hamilton. Precision medicine program at Cook Children’s Medical Center: Early days. Accepted for poster presentation at ASPHO, 2025.
L Hamilton, H Trinkman, W Stigall, A Hoeft, A Ray. Precision medicine as a service: Cook Children's Precision Medicine Program. TCU Faculty Research Symposium, 2024.
A Maniyar, F Acosta, L Hamilton. Use of non allele specific antisense oligonucleotides in treatment of hypomyelinating leukodystrophy. UNTHSC PRP Fall Updates, 2024.
Wojciechowska N, Murray L, Aguilar R, Ray A. Immunotherapy in Pediatrics. Accepted for presentation at: American Society of Pediatric Hematology and Oncology Conference; 2024 Apr 3-6; Seattle, WA
Wojciechowska N, Murray L, Aguilar R, Ray A. Osteoblastoma: A Case Series. Accepted for presentation at: American Society of Pediatric Hematology and Oncology Conference; 2024 Apr 3-6; Seattle, WA
Wojciechowska N, Burke S, Ray A. Congenital Multi-system Langerhans Cell Histiocytosis Responding to Targeted Therapy with Trametinib. Accepted for presentation at: American Society of Pediatric Hematology and Oncology Conference; 2024 Apr 3-6; Seattle, WA
Orr K, Rotolo S, Jernigan H, Koentz M, Wojciechowska N, Ray A. Creation of a Tumor Molecular Testing Registry: An Update. Accepted for presentation at: American Society of Pediatric Hematology and Oncology Conference; 2024 Apr 3-6; Seattle, WA
Keane M, Wojciechowska N, Ray A. Role of Medical Students in a Pediatric Oncology Precision Medicine Clinic. Accepted for presentation at: American Society of Pediatric Hematology and Oncology Conference; 2024 Apr 3- 6; Seattle, W
Wojciechowska N, Diaz M, Ray A. Children with Langerhans Cell Histiocytosis Treated with MEK Inhibitor, Trametinib, Front-line and at Relapse. Accepted for presentation at: 40^th Annual Meeting of the Histiocytes Society; 2024 Nov 6-9; Goa, India

Oral Presentations

L Hamilton, M Cousin, H Kaufmann, J Ziobro, E Berry-Kravis. Building a nano-rare network and managing institutional challenges. n-Lorem 2nd Annual Nano-rare Patient Colloquium, 2024.
L Hamilton. Precision medicine as a service. Cook Children's Pediatric Endocrine Conference, 2024.
L Hamilton. Precision Medicine. Cook Children's Foundation Research Information Session, 2024.
L Hamilton, D Shahani. Patient focused introduction to research. Cook Children's Research Symposium, 2024.
A Ray, K Orr, N Wojciechowska, H Trinkman, L Hamilton. Precisely! Precision medicine and pharmacogenomics at Cook Children's. Presented at Pediatric Grand Rounds, 2024.

$50,000 – Blue Peaks Giving Circle; Genomic Investigative Functional Testing and Treatment Fund

Meet our researchers

Luke Hamilton, Manager, Research Data Science and Analytics | Precision Medicine Research

I was born in Irving, Texas where I attended high school and met my wife. We moved to Abilene, Texas to attend Hardin-Simmons University where I completed my bachelor's degree. I then attended the University of North Texas Health Science Center where I earned my master's degree. Prior to working at Cook Children's, I worked as a scientist in an immunogenomics laboratory where I developed TCR-mimic antibodies, and a pain management medical device company where I developed a three dimensional skin simulator used to visualize radiofrequency ablations. While at Cook Children's, I have worked as a clinical scientist for endocrinology and genetics, and have authored over 25 publications and written 2 textbook chapters. Outside of work, I enjoy spending time with my wife and two boys and staying active through running, weight training, and hiking.

Google Scholar: ‪Luke Hamilton‬ - ‪Google Scholar‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬

ResearchGate LinkedIn

luke.hamilton@cookchildrens.org